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Article

Relative quantification of 40 nucleic acid sequences by multiplex ligation-dependent probe amplification.

Nucleic acids research - 15 Jun 2002

Schouten Jan P, McElgunn Cathal J, Waaijer Raymond, Zwijnenburg Danny, Diepvens Filip, Pals Gerard

Abstract excerpt

We describe a new method for relative quantification of 40 different DNA sequences in an easy to perform reaction requiring only 20 ng of human DNA. Applications shown of this multiplex ligation-dependent probe amplification (MLPA) technique include the detection of exon deletions and duplications in the human BRCA1, MSH2 and MLH1 genes, detection of trisomies such as Down's syndrome, characterisation of...

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Source

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Identifiers

PMID: 12060695
DOI: 10.1093/nar/gnf056
PMCID: PMC117299

Genes

BRCA1
MLH1
MSH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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