Article
High-throughput genotyping of single nucleotide polymorphisms using new biplex invader technology.
Nucleic acids research - 15 Jun 2002
Olivier Michael, Chuang Lee-Ming, Chang Mau-Song, Chen Ying-Tsung, Pei Dee, Ranade Koustubh, de Witte Anniek, Allen Jennifer, Tran Nguyet, Curb David, Pratt Richard, Neefs Henk, de Arruda Indig Monika, Law Scott, Neri Bruce, Wang Lu, Cox David R
Abstract excerpt
The feasibility of large-scale genome-wide association studies of complex human disorders depends on the availability of accurate and efficient genotyping methods for single nucleotide polymorphisms (SNPs). We describe a new platform of the invader assay, a biplex assay, where both alleles are interrogated in a single reaction tube. The assay was evaluated on over 50 different SNPs, with over 20 SNPs genotyped in...
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