Article
IL-24 protects against Salmonella typhimurium infection by stimulating early neutrophil Th1 cytokine production, which in turn activates CD8+ T cells.
European journal of immunology - 1 Dec 2009
Ma Yunfeng, Chen Haidan, Wang Qilong, Luo Fengling, Yan Jun, Zhang Xiao-Lian
Abstract excerpt
Salmonella are important intracellular pathogens in humans and other animal hosts. IL-24 is a novel tumour suppressor and can mediate induction of Th1-type cytokines from PBMC. However, the immunological consequences of this cytokine during intracellular pathogen infection in vivo remain unclear. In the present study, we used a virulent S. typhimurium C5 infected mouse model of typhoid fever to demonstrate that...
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