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Article

Patchy field defects of apoptosis resistance and dedifferentiation in flat mucosa of colon resections from colon cancer patients.

Annals of surgical oncology - 1 Jun 2002

Bernstein Harris, Holubec Hana, Warneke James A, Garewal Harinder, Earnest David L, Payne Claire M, Roe Denise J, Cui Haiyan, Jacobson Elaine L, Bernstein Carol

Abstract excerpt

BACKGROUND: Abnormal areas in normal-appearing flat colonic mucosa (field defects) may predispose individuals to colon cancer. Markers of field defects would indicate cancer risk. METHODS: We evaluated apoptosis capability, dedifferentiation, frequency of simple aberrant crypts, aberrant crypt foci, microadenomas, and total nicotinamide adenine dinucleotide levels at locations within normal-appearing flat mucosa...

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Source

Identifiers

PMID: 12052764
DOI: 10.1007/BF02557276

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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