Article
Filamentous phage integration requires the host recombinases XerC and XerD.
Nature - 6 Jun 2002
Huber Kathryn E, Waldor Matthew K
Abstract excerpt
Many bacteriophages and animal viruses integrate their genomes into the chromosomal DNA of their hosts as a method of promoting vertical transmission. Phages that integrate in a site-specific fashion encode an integrase enzyme that catalyses recombination between the phage and host genomes. CTX phi is a filamentous bacteriophage that contains the genes encoding cholera toxin, the principal virulence factor of the...
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