Article
[Inhibitory effect of all-trans-retinoid and polyphenon-100 on microsatellite instability in a colon cancer line].
Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics - 1 Jun 2002
Ye Jian, Lu Hua, Zhou Jianwei, Wu Hanxin, Wang Chenya
Abstract excerpt
OBJECTIVE: To investigate the effects of all-trans-retinoic acid(ATRA) and polyphenon-100 (PP) on genetic instability of human tumor cells via their role in alteration of microsatellite sequence(MS) and the expression of mismatch repair gene hMLH(1) and hMSH(2) in RER(+) (replication error) cells. METHODS: RER(+) colon cancer cell line was used as a host for lipofection with pCMV-CAR in which a foreign (CA)(14)...
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