Article
In Vivo Identification of the Mitogen-Activated Protein Kinase Cascade as a Central Pathogenic Pathway in Experimental Mesangioproliferative Glomerulonephritis
1 Jun 2002
Abstract excerpt
Evidence was recently provided for the activation of extracellular signal-regulated kinase (ERK), the best characterized mitogen-activated protein kinase, as an intracellular convergence point for mitogenic stimuli in animal models of glomerulonephritis (GN). In this study, in vivo ERK activity was blocked, with a pharmacologic inhibitor (U0126) of the ERK-activating kinase, in rats with mesangioproliferative GN....
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