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Article

Signaling Pathways Implicated in the Stimulation of β-Cell Proliferation by Extracellular Matrix

15 May 2009

Abstract excerpt

Laminin-5-rich extracellular matrix derived from 804G cells (804G-ECM) induces spreading, improves glucose-stimulated insulin secretion, and increases survival and proliferation of rat pancreatic beta-cells. The aim of the study was to determine growth signaling pathways activated by ECM with a particular focus on Ca(2+)-dependent transcription factors. 804G-ECM increased rat beta-cell proliferation, and this...

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Share to Metabolism, Diabetes, and Cancer
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PMID: 19443607
DOI: 10.1210/me.2009-0008

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