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Article

Prothrombotic genotypes are not associated with pre-eclampsia and gestational hypertension: results from a large population-based study and systematic review.

Thrombosis and haemostasis - 1 May 2002

Morrison E R, Miedzybrodzka Z H, Campbell D M, Haites N E, Wilson B J, Watson M S, Greaves M, Vickers M A

Abstract excerpt

DNA samples collected as part of a large population-based case-control study were genotyped to examine the associations of five prothrombotic gene polymorphisms with pre-eclampsia (PE) and gestational hypertension (GH). The polymorphisms studied were: G1691A in Factor V (Factor V Leiden; FVL), prothrombin G20210A, methylenetetrahydrofolate reductase (MTHFR) C677T, plasminogen activator inhibitor-1 4G/5G and the...

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PMID: 12038776

Genes

MTHFR

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Prothrombotic genotypes are not associated with pre-eclampsia and gestational hypertension: results from a large population-based study and systematic review.PMID 12038776Read ↗

Maternal and fetal inherited thrombophilias are not related to the development of severe preeclampsia.Semantic proximity Read ↗

Factor V Leiden is associated with pre-eclampsia but not with fetal growth restriction: a genetic association study and meta-analysis.Semantic proximity Read ↗

Prothrombotic genotypes and pre-eclampsia.Semantic proximity Read ↗

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Genetic thrombophilias and preeclampsia: a meta-analysis.Semantic proximity Read ↗

Inherited thrombophilia polymorphisms and pregnancy outcomes in nulliparous women.Semantic proximity Read ↗

Frequency of factor V, prothrombin and methylenetetrahydrofolate reductase gene variants in preeclampsia.Semantic proximity Read ↗

Prothrombin Gene G20210A Mutation and Obstetric ComplicationsSemantic proximity Read ↗

Thrombophilia and venous thromboembolism in pregnancy: a meta-analysis of genetic risk.Semantic proximity Read ↗

The search for thrombophilic gene mutations in women with gestational hypertension does not help in predicting poor pregnancy outcome.Semantic proximity Read ↗

The G20210A prothrombin-gene mutation and the plasminogen activator inhibitor (PAI-1) 5G/5G genotype are associated with early onset of severe preeclampsia.Semantic proximity Read ↗

The PAI-1 4G/5G polymorphism is not associated with an increased risk of adverse pregnancy outcome in asymptomatic nulliparous women.Semantic proximity Read ↗

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