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Article

The PAI-1 4G/5G polymorphism is not associated with an increased risk of adverse pregnancy outcome in asymptomatic nulliparous women.

Journal of thrombosis and haemostasis : JTH - 1 May 2012

Said J M, Tsui R, Borg A J, Higgins J R, Moses E K, Walker S P, Monagle P T, Brennecke S P

Abstract excerpt

BACKGROUND: Plasminogen activator inhibitor type 1 (PAI-1) is an important regulator of fibrinolysis. A common deletion polymorphism that results in a sequence of 4G instead of 5G in the promoter region of the gene is associated with a small increase in the risk of venous thromboembolism. Its potential association with adverse pregnancy events remains controversial. OBJECTIVE: We aimed to assess the impact of the...

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Source

Identifiers

PMID: 22432640
DOI: 10.1111/j.1538-7836.2012.04700.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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