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Article

Placental overgrowth in mice lacking the imprinted gene <i>Ipl</i>

21 May 2002

Abstract excerpt

The Ipl (Tssc3) gene lies in an extended imprinted region of distal mouse chromosome 7, which also contains the Igf2 gene. Expression of Ipl is highest in placenta and yolk sac, where its mRNA is derived almost entirely from the maternal allele. Ipl encodes a small cytoplasmic protein with a pleckstrin-homology (PH) domain. We constructed two lines of mice with germ-line deletions of this gene (Ipl(neo) and...

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Share to Epigenetics and DNA Methylation
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PMID: 12032310
DOI: 10.1073/pnas.122039999

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