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Article

Microphthalmia-associated transcription factor interacts with LEF-1, a mediator of Wnt signaling.

The EMBO journal - 3 Jun 2002

Yasumoto Ken-ichi, Takeda Kazuhisa, Saito Hideo, Watanabe Ken-ichi, Takahashi Kazuhiro, Shibahara Shigeki

Abstract excerpt

Wnt signals regulate differentiation of neural crest cells through the beta-catenin associated with a nuclear mediator of the lymphoid-enhancing factor 1 (LEF-1)/T-cell factors (TCFs) family. Here we show the interaction between the basic helix-loop-helix and leucine-zipper region of microphthalmia-associated transcription factor (MITF) and LEF-1. MITF is essential for melanocyte differentiation and its...

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Source

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Identifiers

PMID: 12032083
DOI: 10.1093/emboj/21.11.2703
PMCID: PMC126018

Genes

MITF
DCT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Microphthalmia-associated transcription factor interacts with LEF-1, a mediator of Wnt signaling.PMID 12032083Read ↗

Microphthalmia-associated transcription factor (MITF): multiplicity in structure, function, and regulation.Semantic proximity Read ↗

Melanocyte-specific microphthalmia-associated transcription factor isoform activates its own gene promoter through physical interaction with lymphoid-enhancing factor 1.Semantic proximity Read ↗

Melanocytes and the microphthalmia transcription factor network.Semantic proximity Read ↗

microphthalmia, a critical factor in melanocyte development, defines a discrete transcription factor family.Semantic proximity Read ↗

Mutations in microphthalmia, the mouse homolog of the human deafness gene MITF, affect neuroepithelial and neural crest-derived melanocytes differently.Semantic proximity Read ↗

The novel mouse microphthalmia mutations Mitfmi-enu5 and Mitfmi-bcc2 produce dominant negative Mitf proteins.Semantic proximity Read ↗

The MiTF/TFE Family of Transcription Factors: Master Regulators of Organelle Signaling, Metabolism, and Stress AdaptationSemantic proximity Read ↗

The microphthalmia transcription factor (MITF) contains two N-terminal domains required for transactivation of osteoclast target promoters and rescue of mi mutant osteoclasts.Semantic proximity Read ↗

Beta-catenin in the melanocyte lineage.Semantic proximity Read ↗

Evidence to suggest that expression of MITF induces melanocyte differentiation and haploinsufficiency of MITF causes Waardenburg syndrome type 2A.Semantic proximity Read ↗

An L1 element intronic insertion in the black-eyed white (Mitf[mi-bw]) gene: the loss of a single Mitf isoform responsible for the pigmentary defect and inner ear deafness.Semantic proximity Read ↗

Wnt signaling pathway involvement in genotypic and phenotypic variations in Waardenburg syndrome type 2 with MITF mutations.Semantic proximity Read ↗

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