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Article

Protein Disulfide Isomerase Endoplasmic Reticulum Protein 57 (ERp57) is Protective Against ALS-Associated Mutant TDP-43 in Neuronal Cells.

Neuromolecular medicine - 11 Jun 2024

Parakh Sonam, Perri Emma R, Vidal Marta, Takalloo Zeinab, Jagaraj Cyril J, Mehta Prachi, Yang Shu, Thomas Colleen J, Blair Ian P, Hong Yuning, Atkin Julie D

Abstract excerpt

Amyotrophic Lateral Sclerosis (ALS) is a severe neurodegenerative disease affecting motor neurons. Pathological forms of Tar-DNA binding protein-43 (TDP-43), involving its mislocalisation to the cytoplasm and the formation of misfolded inclusions, are present in almost all ALS cases (97%), and ~ 50% cases of the related condition, frontotemporal dementia (FTD), highlighting its importance in neurodegeneration....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38861223
DOI: 10.1007/s12017-024-08787-0
PMCID: PMC11166824

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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