Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Dihydrofolate reductase gene polymorphisms in Pneumocystis carinii f. sp. hominis in Japan.

Journal of medical microbiology - 1 Jun 2002

Takahashi Takashi, Endo Tokiomi, Nakamura Tetsuya, Sakashita Hiroyuki, Kimura Kyoko, Ohnishi Kenji, Kitamura Yoshihiro, Iwamoto Aikichi

Abstract excerpt

This study examined polymorphisms in the dihydrofolate reductase (DHFR) gene of Pneumocystis carinii isolates from 27 patients with P. carinii pneumonia (PCP) in Japan. Four substitution sites with two synonymous and two non-synonymous changes were found. Two synonymous substitutions at nucleotide positions 540 and 312 were identified in one and 13 patients, respectively. Two amino acid substitutions (Ala67Val,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Dihydropteroate Synthase
Share to Anti-Infective Agents

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Bronchoalveolar Lavage Fluid

Share to Immunocompromised Host

Share to Pneumocystis

Share to Pneumonia, Pneumocystis

Share to Tetrahydrofolate Dehydrogenase

Share to Trimethoprim, Sulfamethoxazole Drug Combination

Source

Identifiers

PMID: 12018659
DOI: 10.1099/0022-1317-51-6-510

Genes

DHFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Dihydrofolate reductase gene polymorphisms in Pneumocystis carinii f. sp. hominis in Japan.PMID 12018659Read ↗

Genetic diversity of drug targets including dihydropteroate synthase, dihydrofolate reductase and cytochrome b, in Pneumocystis carinii f. sp. hominis isolates in Japan.Semantic proximity Read ↗

Relationship between mutations in dihydropteroate synthase of Pneumocystis carinii f. sp. hominis isolates in Japan and resistance to sulfonamide therapy.Semantic proximity Read ↗

Genetic Divergence of the Dihydrofolate Reductase and Dihydropteroate Synthase Genes inPneumocystis cariniifrom 7 Different Host SpeciesSemantic proximity Read ↗

Genetic characterization of the dihydrofolate reductase gene of Pneumocystis jirovecii isolates from Portugal.Semantic proximity Read ↗

Dihydropteroate synthase polymorphisms in Pneumocystis carinii.Semantic proximity Read ↗

Genetic analysis of multiple loci suggests that mutations in the Pneumocystis carinii f. sp. hominis dihydropteroate synthase gene arose independently in multiple strains.Semantic proximity Read ↗

Pneumocystis carinii dihydropteroate synthase but not dihydrofolate reductase gene mutations correlate with prior trimethoprim-sulfamethoxazole or dapsone use.Semantic proximity Read ↗

Increase in prevalence of Pneumocystis carinii mutations in patients with AIDS and P. carinii pneumonia, in the United States and China.Semantic proximity Read ↗

Typing of Pneumocystis carinii strains that infect humans based on nucleotide sequence variations of internal transcribed spacers of rRNA genes.Semantic proximity Read ↗

Distribution of DHPS mutations among ITS subtypes of P. carinii f. sp. hominis.Semantic proximity Read ↗

Molecular detection of DHFR gene polymorphisms in Pneumocystis jirovecii isolates from Indian patients.Semantic proximity Read ↗

Genetic variation in Pneumocystis carinii isolates from different geographic regions: implications for transmission.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.