Article
Genetic variation in Pneumocystis carinii isolates from different geographic regions: implications for transmission.
Emerging infectious diseases - 1 Jan 2000
Beard C B, Carter J L, Keely S P, Huang L, Pieniazek N J, Moura I N, Roberts J M, Hightower A W, Bens M S, Freeman A R, Lee S, Stringer J R, Duchin J S, del Rio C, Rimland D, Baughman R P, Levy D A, Dietz V J, Simon P, Navin T R
Abstract excerpt
To study transmission patterns of Pneumocystis carinii pneumonia (PCP) in persons with AIDS, we evaluated P. carinii isolates from patients in five U.S. cities for variation at two independent genetic loci, the mitochondrial large subunit rRNA and dihydropteroate synthase. Fourteen unique multilocus genotypes were observed in 191 isolates that were examined at both loci. Mixed infections, accounting for 17.8% of...
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