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Genetic Divergence of the Dihydrofolate Reductase and Dihydropteroate Synthase Genes inPneumocystis cariniifrom 7 Different Host Species

15 Nov 2001

Abstract excerpt

To investigate the phylogenetic and therapeutic implications of the genetic divergence in the dihydrofolate reductase (DHFR) and dihydropteroate synthase (DHPS) genes among different Pneumocystis carinii strains, these 2 genes in P. carinii obtained from 7 different host species were sequenced. Pairwise comparison of the DHPS sequences demonstrated 6%-24% and 6%-30% divergence in the nucleotide and deduced amino...

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PMID: 11679931
DOI: 10.1086/324208

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