Article
N-acetyltransferase 2 single-nucleotide polymorphisms and risk of gastric carcinoma.
European journal of clinical pharmacology - 1 May 2002
Ladero José M, Agúndez José A G, Olivera Manuela, Lozano Luis, Rodríguez-Lescure Alvaro, Diaz-Rubio Manuel, Benítez Julio
Abstract excerpt
OBJECTIVE: To explore whether an association exists between the NAT2 genotype and the risk of developing gastric cancer.METHODS. Ninety-nine patients with gastric adenocarcinoma and 258 healthy subjects were analysed for single-nucleotide polymorphisms at the NAT2 gene locus, which give rise to gene variants known to be associated with slow-acetylation status. RESULTS: The functional NAT2*4 (wild-type) allele is...
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