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A Functional Assay to Assess Toxicity During Murine B Cell Development In Vitro.

Current protocols in toxicology - 1 Mar 2020

Guilbert Cynthia, Chou Hsiang, Bolt Alicia M, Wu Ting Hua, Luo Vincent Mingyi, Orthwein Alexandre, Mann Koren K

Abstract excerpt

B lymphocytes, or B cells, are important players in immunity that produce antigen-specific immunoglobulins. As a result, they are involved in various immune-linked pathologies. To better understand, prevent, or treat B cell-associated disease and immunotoxicity, we developed an in vitro assay to model early murine B cell differentiation within the bone marrow. This model uses sorted B cell precursors cultured on...

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Identifiers

PMID: 31851434
DOI: 10.1002/cptx.91

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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