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Article

Analysis of homozygous deletion of the p16 gene and correlation with survival in patients with glioblastoma multiforme

1 May 2002

Abstract excerpt

OBJECT: One of the most frequent genetic abnormalities found in patients with glioblastoma multiforme (GBM) is homozygous deletion of the p16 tumor suppressor gene. The authors investigated whether this deletion is associated with prognosis in patients with GBM. METHODS: In 46 adult patients with supratentorial GBM, homozygous deletion of the p16 gene in tumor DNA was examined using the multiplex polymerase chain...

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PMID: 12005388
DOI: 10.3171/jns.2002.96.5.0815

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