Article
Functional importance of calcium binding sites in outer membrane phospholipase A.
Biochimica et biophysica acta - 12 Apr 2002
Kingma Roelie L, Snijder Harm J, Dijkstra Bauke W, Dekker Niek, Egmond Maarten R
Abstract excerpt
Outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that hydrolyses phospholipids requiring Ca(2+) as cofactor. In vitro studies have shown that OMPLA is only active as a dimer. The structures of monomeric and dimeric OMPLA provided possible clues to the activation process. In the inhibited dimeric species calcium ions are located at the dimer interface ideally suited to stabilise the oxyanion...
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