Article
A hypermutator phenotype attenuates the virulence of Listeria monocytogenes in a mouse model.
Molecular microbiology - 1 May 2002
Mérino Delphine, Réglier-Poupet Hélène, Berche Patrick, Charbit Alain
Abstract excerpt
The integrity of the genetic material of bacteria is guaranteed by a set of distinct repair mechanisms. The participation of these repair systems in bacterial pathogenicity has been addressed only recently. Here, we study for the first time the participation in virulence of the MutSL mismatch repair system of Listeria monocytogenes. The mutS and mutL genes, which are contiguous in the L. monocytogenes chromosome,...
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