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Fetal Gene Transfer by Intrauterine Injection with Microbubble-Enhanced Ultrasound

1 May 2002

Abstract excerpt

Intrauterine injection of naked DNA expressing luciferase, green fluorescent protein (GFP), or beta-galactosidase (beta-gal) and fluorescein isothiocyanate-labeled oligodeoxynucleotide (FITC-ODN), in combination with microbubble-enhanced ultrasound (US), referred to as the "shotgun method" (SGM), produced high-level protein expression in fetal mice. With the SGM, luciferase expression increased approximately...

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Identifiers

PMID: 11991740
DOI: 10.1006/mthe.2002.0577

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