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Article

Contact-dependent demyelination by Mycobacterium leprae in the absence of immune cells.

Science (New York, N.Y.) - 3 May 2002

Rambukkana Anura, Zanazzi George, Tapinos Nikos, Salzer James L

Abstract excerpt

Demyelination results in severe disability in many neurodegenerative diseases and nervous system infections, and it is typically mediated by inflammatory responses. Mycobacterium leprae, the causative organism of leprosy, induced rapid demyelination by a contact-dependent mechanism in the absence of immune cells in an in vitro nerve tissue culture model and in Rag1-knockout (Rag1-/-) mice, which lack mature B and...

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Identifiers

PMID: 11988579
DOI: 10.1126/science.1067631

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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