Article
The IL12B gene does not confer susceptibility to coeliac disease.
Tissue antigens - 1 Jan 2002
Louka A S, Torinsson Naluai A, D'Alfonso S, Ascher H, Coto I, Ek J, Giordano M, Gudjónsdóttir A H, Mellai M, Momigliano-Richiardi P, Percopo S, Samuelsson L, Wahlström J, Greco L, Sollid L M
Abstract excerpt
Coeliac disease (CD) is a chronic inflammatory disorder where dietary gluten is not tolerated. In the lesion there are gluten reactive T cells predominantly secreting gamma-interferon. Both HLA and non-HLA genes contribute to CD susceptibility. Interleukin-12 (IL-12) regulates gamma-interferon production. The IL12B gene is located in a region (5q31.1-33.1) where there is evidence for linkage with CD. Allele 1 of...
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