Article
Gm typing of Irish coeliac patients and controls does not help locate the "second" coeliac gene.
Irish journal of medical science - 1 Feb 1991
Hannigan M, Bourke M, Stevens F M, McCarthy C F
Abstract excerpt
A two gene model has been proposed to explain the inheritance of coeliac disease (CD). One gene is on chromosome 6 in the MHC complex (HLA associated). It has been suggested the second gene is located on chromosome 14, in or near the region encoding for immunoglobulin heavy chain allotypes (Gm types). In a study of 102 unrelated Irish coeliacs and a group of ethnic controls, we have failed to show an association...
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