Identification of the streptococcal M protein binding site on membrane cofactor protein (CD46).

doi:10.4049/jimmunol.168.9.4585

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Article

Identification of the streptococcal M protein binding site on membrane cofactor protein (CD46).

Journal of immunology (Baltimore, Md. : 1950) - 1 May 2002

Giannakis Eleni, Jokiranta T Sakari, Ormsby Rebecca J, Duthy Thomas G, Male Dean A, Christiansen Dale, Fischetti Vince A, Bagley Chris, Loveland Bruce E, Gordon David L

Abstract excerpt

Adherence of group A streptococcus (GAS) to keratinocytes is mediated by an interaction between human CD46 (membrane cofactor protein) with streptococcal cell surface M protein. CD46 belongs to a family of proteins that contain structurally related short consensus repeat (SCR) domains and regulate the activation of the complement components C3b and/or C4b. CD46 possesses four SCR domains and the aim of this study...

Topics

Amino Acid Sequence
Antigens, Bacterial
Antigens, CD
Bacterial Adhesion
Bacterial Outer Membrane Proteins
Binding Sites
Carrier Proteins
Cell Line
Complement C3b
Conserved Sequence

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Keratinocytes

Membrane Cofactor Protein

Membrane Glycoproteins

Models, Molecular

Molecular Sequence Data

Mutation

Protein Structure, Tertiary

Source

Open in PubMed

Identifiers

PMID: 11971006
DOI: 10.4049/jimmunol.168.9.4585

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