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Article

Identification of the streptococcal M protein binding site on membrane cofactor protein (CD46).

Journal of immunology (Baltimore, Md. : 1950) - 1 May 2002

Giannakis Eleni, Jokiranta T Sakari, Ormsby Rebecca J, Duthy Thomas G, Male Dean A, Christiansen Dale, Fischetti Vince A, Bagley Chris, Loveland Bruce E, Gordon David L

Abstract excerpt

Adherence of group A streptococcus (GAS) to keratinocytes is mediated by an interaction between human CD46 (membrane cofactor protein) with streptococcal cell surface M protein. CD46 belongs to a family of proteins that contain structurally related short consensus repeat (SCR) domains and regulate the activation of the complement components C3b and/or C4b. CD46 possesses four SCR domains and the aim of this study...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Bacterial Outer Membrane Proteins

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Source

Identifiers

PMID: 11971006
DOI: 10.4049/jimmunol.168.9.4585

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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