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Strength of Envelope Protein Interaction Modulates Cytopathicity of Measles Virus

15 May 2002

Abstract excerpt

To understand the molecular determinants of measles virus (MV) cytopathicity, we have characterized mutant viruses exhibiting a more-extensive cell-to-cell fusion while maintaining efficient replication to high titers. A virus which is modified by the addition of an 8-amino-acid Flag epitope tag at the cytoplasmic tail of its H (for MV hemagglutinin) envelope glycoprotein replicates efficiently, has an increased...

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PMID: 11967321
DOI: 10.1128/jvi.76.10.5051-5061.2002

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