Article
Lack of association between T-786-->C mutation in the 5'-flanking region of the endothelial nitric oxide synthase gene and essential hypertension.
Hypertension research : official journal of the Japanese Society of Hypertension - 1 Nov 2000
Kajiyama N, Saito Y, Miyamoto Y, Yoshimura M, Nakayama M, Harada M, Kuwahara K, Kishimoto I, Yasue H, Nakao K
Abstract excerpt
Accumulating evidence strongly suggests that an alteration in nitric oxide metabolism is involved in the pathogenesis of hypertension. We recently found 2 polymorphisms in the endothelial nitric oxide synthase (eNOS) gene, a Glu298Asp missense variant in exon 7 and a T-786-->C variant in the 5'-flanking region, which are not linked to each other. In our previous reports, we showed a positive association between...
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