Article
Breast cancer risk in Ashkenazi BRCA1/2 mutation carriers: effects of reproductive history.
Epidemiology (Cambridge, Mass.) - 1 May 2002
Hartge Patricia, Chatterjee Nilanjan, Wacholder Sholom, Brody Lawrence C, Tucker Margaret A, Struewing Jeffery P
Abstract excerpt
BACKGROUND: Younger age at first birth and greater parity generally reduce the risk of developing breast cancer, but whether this reduced risk holds in women with a mutation in the BRCA1 or BRCA2 gene is unknown. METHODS: In a Washington DC community-based study conducted in 1996, we tested 5318 Ashkenazi Jews for three BRCA1/2 founder mutations and identified 120 mutation carriers. Applying an extension of the...
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