Article
Optical projection tomography as a tool for 3D microscopy and gene expression studies.
Science (New York, N.Y.) - 19 Apr 2002
Sharpe James, Ahlgren Ulf, Perry Paul, Hill Bill, Ross Allyson, Hecksher-Sørensen Jacob, Baldock Richard, Davidson Duncan
Abstract excerpt
Current techniques for three-dimensional (3D) optical microscopy (deconvolution, confocal microscopy, and optical coherence tomography) generate 3D data by "optically sectioning" the specimen. This places severe constraints on the maximum thickness of a specimen that can be imaged. We have developed a microscopy technique that uses optical projection tomography (OPT) to produce high-resolution 3D images of both...
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