Article
Premature arterial and venous events in three families. Effect of folate levels and MTHFR mutation mediated by family/generation and homocysteine levels.
Thrombosis research - 15 Jan 2002
Assanelli Deodato, Grassi M, Bonanome A, Salvadori G, Bonetti P, Boldini A, Archetti S, Ruggeri G, Pezzini A, Pagnan A
Abstract excerpt
Plasma homocysteine levels result from the effect of genetic and environmental factors. We investigated the hypothesis of familial association between folates, methylenetetrahydrofolate reductase (MTHFR) and hyperhomocysteinemia with acute events, studying three families through pedigree analysis and log-linear graphical models. In 43 subjects, 13 had homocysteine levels of >15 micromol/l. In Family A, premature...
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