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Article

Determination of thiopurine S-methyltransferase phenotype using thin-layer chromatography and quantitative scanning.

European journal of clinical pharmacology - 1 Apr 2002

Dauer Marc, Schulze Johannes, Loher Florian, Endres Stefan, Eigler Andreas

Abstract excerpt

OBJECTIVE: To develop a non-high-performance liquid chromatography method for the determination of thiopurine- S-methyltransferase (TPMT) phenotype using thin-layer chromatography and quantitative scanning. METHODS: TPMT reaction was performed using a radiochemical assay. The reaction product [(14)C]-6-methylmercaptopurine was separated using thin-layer chromatography and quantified by means of radioactive...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 11956672
DOI: 10.1007/s00228-001-0406-5

Genes

TPMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Determination of thiopurine S-methyltransferase phenotype using thin-layer chromatography and quantitative scanning.PMID 11956672Read ↗

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Thiopurine S-Methyltransferase as a Pharmacogenetic Biomarker: Significance of Testing and Review of Major Methods.Semantic proximity Read ↗

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Thiopurine S-methyltransferase genotype-phenotype concordance: used as a quality assurance tool to help control the phenotype assay.Semantic proximity Read ↗

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