Article
Analysis of T cell receptors reactive with squamous cell carcinoma antigen SART-1 presented by the HLA-A24 molecule.
Oncology reports - 1 Jan 2000
Shimizu Katsuhiko, Yamaguchi Yoshiyuki, Ohta Koji, Miyahara Eiji, Toge Tetsuya
Abstract excerpt
We investigated the induction of cytotoxic T lymphocytes (CTLs) specific for squamous cell carcinoma antigen SART-1 from the peripheral blood mononuclear cells (PBMCs) of an HLA-A24 healthy donor by in vitro stimulation with dendritic cells (DCs) pulsed with the antigenic peptide. Effector cells, designated as <peptide-pulsed dendritic cell-activated killer (PDAK)> cells, exhibited potent cytotoxic activity...
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