The susceptibility sequence to rheumatoid arthritis is a cross-reactive B cell epitope shared by the Escherichia coli heat shock protein dnaJ and the histocompatibility leukocyte antigen DRB10401 molecule.

doi:10.1172/JCI115580

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Article

The susceptibility sequence to rheumatoid arthritis is a cross-reactive B cell epitope shared by the Escherichia coli heat shock protein dnaJ and the histocompatibility leukocyte antigen DRB10401 molecule.

The Journal of clinical investigation - 1 Jan 1992

Albani S, Tuckwell J E, Esparza L, Carson D A, Roudier J

Abstract excerpt

Immunological responses to bacterial heat shock proteins have been implicated in the pathogenesis of arthritis in animals and humans. The predicted amino acid sequence of dnaJ, a heat shock protein from Escherichia coli, contains an 11-amino acid segment that is homologous to the third hypervaria...

Topics

Amino Acid Sequence
Arthritis, Rheumatoid
B-Lymphocytes
Bacterial Proteins
Cross Reactions
Epitopes
Escherichia coli
Escherichia coli Proteins
Genetic Variation
HLA-D Antigens
HSP40 Heat-Shock Proteins
Heat-Shock Proteins
Humans

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Immunoglobulin Fab Fragments

Molecular Sequence Data

Sequence Homology, Nucleic Acid

Source

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Identifiers

PMID: 1370300
DOI: 10.1172/JCI115580
PMCID: PMC442852

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1370300-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.