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Article

Construction and analyses of tetrameric forms of yeast NAD+-specific isocitrate dehydrogenase.

Biochemistry - 18 Jan 2011

Lin An-Ping, Demeler Borries, Minard Karyl I, Anderson Sondra L, Schirf Virgil, Galaleldeen Ahmad, McAlister-Henn Lee

Abstract excerpt

Yeast NAD(+)-specific isocitrate dehydrogenase (IDH) is an octameric enzyme composed of four heterodimers of regulatory IDH1 and catalytic IDH2 subunits. The crystal structure suggested that the interactions between tetramers in the octamer are restricted to defined regions in IDH1 subunits from each tetramer. Using truncation and mutagenesis, we constructed three tetrameric forms of IDH. Truncation of five...

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Source

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Identifiers

PMID: 21133413
DOI: 10.1021/bi101401h
PMCID: PMC3137751

Genes

IDH1
IDH2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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