Transcriptional Activation of sclA by Mga Requires a Distal Binding Site in Streptococcus pyogenes

doi:10.1128/jb.186.23.7847-7857.2004

Article

Transcriptional Activation of sclA by Mga Requires a Distal Binding Site in Streptococcus pyogenes

16 Nov 2004

Abstract excerpt

Streptococcus pyogenes (the group A streptococcus [GAS]) is a medically significant pathogen of humans, causing a range of diseases from pharyngitis to necrotizing fasciitis. Several important GAS virulence genes are under the control of a pleiotropic regulator called Mga, or the multiple gene regulator of GAS, including the gene encoding the streptococcal collagen-like protein, or sclA. Analysis of the genome...

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