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Article

The importin-beta P446L dominant-negative mutant protein loses RanGTP binding ability and blocks the formation of intact nuclear envelope.

Journal of cell science - 15 Apr 2002

Timinszky Gyula, Tirián László, Nagy Ferenc T, Tóth Gábor, Perczel András, Kiss-László Zsuzsanna, Boros Imre, Clarke Paul R, Szabad János

Abstract excerpt

Three of the four independently induced Ketel(D) dominantnegative female sterile mutations that identify the Drosophila importin-beta gene, originated from a C4114--> T transition and the concurrent replacement of Pro446 by Leu (P446L). CD spectroscopy of representative peptides with Pro or Leu in the crucial position revealed that upon the Pro-->Leu exchange the P446L mutant protein loses flexibility and attains...

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PMID: 11950886
DOI: 10.1242/jcs.115.8.1675

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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