Article
Recurrent DNA sequence copy losses on chromosomal arm 6q in capillary hemangioblastoma.
Cancer genetics and cytogenetics - 1 Mar 2002
Lemeta Sebsebe, Aalto Yan, Niemelä Mika, Jääskeläinen Juha, Sainio Markku, Kere Juha, Knuutila Sakari, Böhling Tom
Abstract excerpt
Capillary hemangioblastomas (CHB) of the central nervous system, the most common tumor in von Hippel-Lindau (VHL) disease, usually show mutations in the VHL tumor suppressor gene on chromosome 3p25-p26. Because little is known concerning the cytogenetic changes in these tumors, we studied 22 cases through comparative genomic hybridization to screen for DNA copy number changes in both sporadic and VHL-associated...
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