Article
Localization of the neuronal class III beta-tubulin in oligodendrogliomas: comparison with Ki-67 proliferative index and 1p/19q status.
Journal of neuropathology and experimental neurology - 1 Apr 2002
Katsetos Christos D, Del Valle Luis, Geddes Jennian F, Aldape Ken, Boyd James C, Legido Agustin, Khalili Kamel, Perentes Elias, Mörk Sverre J
Abstract excerpt
The class III beta-tubulin isotype (betaIII) is widely regarded as a neuronal marker in development and neoplasia. Whereas the expression of betaIII in neuronal/neuroblastic tumors is differentiation-dependent, the aberrant expression of this cytoskeletal protein in astrocytomas is associated with an ascending gradient of malignancy. To test the generality of this observation we have compared the immunoreactivity...
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