Article
The nuclear genome of a Drosophila mutant strain increases the frequency of rearranged mitochondrial DNA molecules.
Current genetics - 1 Feb 2002
Le Goff Samuel, Lachaume Philippe, Touraille Sylvie, Alziari Serge
Abstract excerpt
We studied a mutant strain of Drosophila subobscura, in which 80% of the mitochondrial genomes (mtDNA) have lost over 30% of the coding region. The mutation is stable and is transmitted identically to offspring. The putative role of the mutant nuclear genome in the production of rearranged mtDNA was investigated using reciprocal crosses, to place the mitochondria of the wild strain in a mutant nuclear context....
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