The structure of human recombinant aldose reductase complexed with the potent inhibitor zenarestat

Abstract excerpt

The crystal structure of the complex of human recombinant aldose reductase (AR) with zenarestat, one of its potent inhibitors, has been solved at 2.5 A resolution. Zenarestat fits neatly in the hydrophobic active site and induces unique and dramatic conformational changes. For example, the benzene ring of zenarestat occupies a gap in the side chains of Leu300 and Trp111 that interact directly and forms a CH-pi...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Aldose Reductase and Taurine
• Share to Heme Oxygenase-1 and Carbon Monoxide
• Share to Neonatal Health and Biochemistry