Article
Identification of human plasma kallikrein gene polymorphisms and evaluation of their role in end-stage renal disease.
Hypertension (Dallas, Tex. : 1979) - 1 Apr 1998
Yu H, Bowden D W, Spray B J, Rich S S, Freedman B I
Abstract excerpt
Kallikreins are serine proteases that release kinins from kininogens. Kinins, via their effects on cardiovascular and renal function, may be involved in the pathogenesis of hypertension and renal failure. Two groups of kallikreins exist, glandular or tissue kallikrein and plasma kallikrein. In this study, we examined the human plasma kallikrein gene KLK3 to determine whether it contributed to end-stage renal...
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