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Article

Shed human enterocytes as a tool for the study of expression and function of intestinal drug-metabolizing enzymes and transporters.

Clinical pharmacology and therapeutics - 1 Mar 2002

Glaeser Hartmut, Drescher Siegfried, van der Kuip Heiko, Behrens Christoph, Geick Anke, Burk Oliver, Dent John, Somogyi Andrew, Von Richter Oliver, Griese Ernst-Ulrich, Eichelbaum Michel, Fromm Martin F

Abstract excerpt

OBJECTIVES: Intestinal metabolism and transport are now recognized as protective barriers against orally ingested xenobiotics, including drugs. However, in vitro studies of the expression and function of intestinal proteins are hampered by the limited availability of human intestinal tissues. Because enterocytes are constantly shed in large numbers into the gut lumen, this study investigated whether these cells...

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Identifiers

PMID: 11907487
DOI: 10.1067/mcp.2002.121370

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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