Molecular aspects of the mammalian cell cycle and cancer.

doi:10.1634/theoncologist.7-1-73

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Article

Molecular aspects of the mammalian cell cycle and cancer.

The oncologist - 1 Jan 2002

Sandal T

Abstract excerpt

Cancer arises mainly from mutations in somatic cells. However, it is not the result of a single mutation, rather, it results from increasing genetic disarray accumulated over time. Tumorigenesis in humans is, therefore, a multistep and age-dependent process. The multiple mechanisms and multiple players involved in this process necessitate an understanding of the molecular mechanisms, in order to distinctively...

Topics

Animals
Cell Cycle
Cyclin-Dependent Kinases
Cyclins
G1 Phase
Gene Expression
Genes, Tumor Suppressor
Genes, p53
Humans
Mammals
Mutation
Neoplasms
Proto-Oncogenes
Retinoblastoma Protein

Source

Open in PubMed

Identifiers

PMID: 11854549
DOI: 10.1634/theoncologist.7-1-73

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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