Cell cycle regulators: mechanisms and their role in aetiology, prognosis, and treatment of cancer.

Abstract excerpt

Tumour cells have sustained derailments in growth control, have escaped from immunological clearing systems, and have acquired immortality as a result of an accumulation of genetic alterations that provide these cells with a selective advantage over others (fig 1). Tumour development is therefore a disease of the DNA and is heritable when these genetic alterations have occurred in the reproductive cells....

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