Article
Visualization of transcription-dependent association of imprinted genes with the nuclear matrix.
Experimental cell research - 1 Apr 2002
Kagotani Kazuhiro, Nabeshima Hiroki, Kohda Atsushi, Nakao Mitsuyoshi, Taguchi Hiroshi, Okumura Katsuzumi
Abstract excerpt
Genomic imprinting is characterized by allele-specific gene expression as a biological phenomenon. To analyze the participation of the nuclear matrix in the expression of imprinted genes, we first examined the allelic expression state of genes by simultaneously visualizing their primary transcripts and the gene sequences in individual cell nuclei using fluorescence in situ hybridization (FISH). We confirmed that...
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