Article
Retroviral transduction of splice variant Brca1-Delta11 or mutant Brca1-W1777Stop causes mouse epithelial mammary atypical duct hyperplasia.
Virchows Archiv : an international journal of pathology - 1 Mar 2002
Bachelier Richard, Vincent Anne, Mathevet Patrice, Magdinier Frédérique, Lenoir Gilbert M, Frappart Lucien
Abstract excerpt
We have investigated the effects of the expression of wild-type and mutant Brca1 alleles on the murine mammary gland morphogenesis and carcinogenesis. Primary cultures of mammary cells from BALB/cByJIco mice were infected with recombinant Babe Puro retroviruses expressing lacZ, full-length Brca1,...
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