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Article

Acquired uniparental disomy of chromosome 9p is a frequent stem cell defect in polycythemia vera.

Experimental hematology - 1 Mar 2002

Kralovics Robert, Guan Yongli, Prchal Josef T

Abstract excerpt

OBJECTIVE: Clonal stem cell proliferation and increased erythrocyte mass are hallmarks of the myeloproliferative disorder polycythemia vera (PV). The molecular basis of PV is unknown. METHODS: We carried out a genome-wide screening for loss of heterozygosity (LOH) and analyzed candidate genes within the LOH loci. RESULTS: Three genomic regions were identified on chromosomes 9p, 10q, and 11q. The presence of these...

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PMID: 11882360
DOI: 10.1016/s0301-472x(01)00789-5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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