Article
A theoretical limit to coding space in chromosomes of bacteria.
Omics : a journal of integrative biology - 1 Jan 2002
Jackson Julius H, Harrison Scott H, Herring Patricia A
Abstract excerpt
A mathematical model of cluster patterns for mapped genes with known phenotypes in Escherichia coli predicted thatfunctional genes may account for a maximum of two-thirds of the total chromosomal space. The corollary prediction was that one-third of the chromosome comprised noncoding space. Open reading frame (ORF) analyses for 15 phylogenetically diverse bacterial genomes and for 30 fully sequenced prokaryotic...
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