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Article

Two fundamentally different classes of microbial genes.

Nature microbiology - 7 Nov 2016

Wolf Yuri I, Makarova Kira S, Lobkovsky Alexander E, Koonin Eugene V

Abstract excerpt

The evolution of bacterial and archaeal genomes is highly dynamic and involves extensive horizontal gene transfer and gene loss1-4. Furthermore, many microbial species appear to have open pangenomes, where each newly sequenced genome contains more than 10% ORFans, that is, genes without detectable homologues in other species5,6. Here, we report a quantitative analysis of microbial genome evolution by fitting the...

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PMID: 27819663
DOI: 10.1038/nmicrobiol.2016.208

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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